Search results for "Marginal model"
showing 5 items of 5 documents
A Critical Review of Statistical Methods for Twin Studies Relating Exposure to Early Life Health Conditions
2021
International audience; When investigating disease etiology, twin data provide a unique opportunity to control for confounding and disentangling the role of the human genome and exposome. However, using appropriate statistical methods is fundamental for exploiting such potential. We aimed to critically review the statistical approaches used in twin studies relating exposure to early life health conditions. We searched PubMed, Scopus, Web of Science, and Embase (2011–2021). We identified 32 studies and nine classes of methods. Five were conditional approaches (within-pair analyses): additive-common-erratic (ACE) models (11 studies), generalized linear mixed models (GLMMs, five studies), gene…
Regression models for multivariate ordered responses via the Plackett distribution
2008
AbstractWe investigate the properties of a class of discrete multivariate distributions whose univariate marginals have ordered categories, all the bivariate marginals, like in the Plackett distribution, have log-odds ratios which do not depend on cut points and all higher-order interactions are constrained to 0. We show that this class of distributions may be interpreted as a discretized version of a multivariate continuous distribution having univariate logistic marginals. Convenient features of this class relative to the class of ordered probit models (the discretized version of the multivariate normal) are highlighted. Relevant properties of this distribution like quadratic log-linear e…
Optimal designs for a one-way layout with covariates
2000
Abstract For the general class of Φ q -criteria optimal designs are characterized which reflect the inherent symmetry in a one-way layout with covariates. In particular, the eigenvalues of the covariance matrices are related to those in suitably chosen marginal models depending on the underlying interaction structure.
Efficiency Bounds for Product Designs in Linear Models
1999
We provide lower efficiency bounds for the best product design for an additive multifactor linear model. The A-optimality criterion is used to demonstrate that out bounds are better than the conventional bounds. Applications to other criteria, such as IMSE (integrated mean squared error) criterion are also indicated. In all the cases, the best product design appears to perform better when there are more levels in each factor but decreases when more factors are included. Explicit efficiency formulas for non-additive models are also constructed.
Estimating regression models with unknown break-points.
2003
This paper deals with fitting piecewise terms in regression models where one or more break-points are true parameters of the model. For estimation, a simple linearization technique is called for, taking advantage of the linear formulation of the problem. As a result, the method is suitable for any regression model with linear predictor and so current software can be used; threshold modelling as function of explanatory variables is also allowed. Differences between the other procedures available are shown and relative merits discussed. Simulations and two examples are presented to illustrate the method.